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(QU-CPH) MSc student conducts a multidisciplinary project between pharmacoeconomics and pharmacogenetics | Qatar University

(QU-CPH) MSc student conducts a multidisciplinary project between pharmacoeconomics and pharmacogenetics

2020-05-07 00:00:00.0
الطالبة سوسن مقداد

Qatar University’s College of Pharmacy (QU-CPH) MSc student in Clinical Pharmacy and Practice, Sawsan AlMukdad defended recently her MSc thesis entitled the ‘Economic Evaluation of the CYP2C19 Genotype-Guided Antiplatelet Therapy Compared to the Universal Use of Ticagrelor or Clopidogrel in Qatar’.
The defense was conducted recently due to suspension of classes for students and precautionary measures to prevent novel coronavirus (COVID-19). Sawsan evaluated the pharmaconomics of CYP2C19 genotype-guided antiplatelet therapy compared to the universal use of antiplatelets after a percutaneous coronary intervention with the acute coronary syndrome.
As a direct response to a request by decision-makers at the Hamad Medical Corporation (HMC), Sawsan evaluated the cost-effectiveness of CYP2C19 genetic test guided therapy compared to the general use of Ticagrelor or Clopidogrel from the hospital perspective of the main healthcare provider in Qatar, the HMC. Using decision-analytic simulation models, this research demonstrated that CYP2C19 genetic-guided therapy is between dominant (higher effect with lower cost) and cost-effective compared to the general use of Clopidogrel and universal Ticagrelor, over the short- and long-term follow up durations, against clinical and quality-adjusted life years outcomes.
The research was conducted under the main supervision of CPH Associate Professor Daoud Al-Badriyeh, co-supervised by CPH Associate Professor Hazem Elewa. Dr. Al-Badriyeh said, “Sawsan’s findings of the high likelihood of the CYP2C19 genetic-guided antiplatelet therapy to be cost-effective approach, therefore, an important and of significant value to the decision making in the Qatari practices, where opportunities for cutting spending on healthcare resources arises.”
About Sawsan, he added, “I supervised many postgraduates over the years. Sawsan is one of the most successful and has put her heart, mind and soul into even the smallest detail in this project. In this case, we have a multidisciplinary project between pharmacoeconomics and pharmacogenetics. Sawsan loved the areas of her research, which is very important. Her resolution to succeed is impressive and will surely take her places.”
Sawsan said, “This analysis is the first economic evaluation in Qatar and the region about CYP2C19 genetic-guided antiplatelet therapy versus universal use of Clopidogrel or Ticagrelor. Further, it includes several methodological aspects that make it unique among similar studies in international settings.”
In relation to her journey as a postgraduate student, Sawsan said: “The College of Pharmacy, under the leadership of Dean Dr. Mohammed Diab, has unlocked the doors of success and a career that I love. I feel attached to this institution as I spent seven years living in its halls, starting with a BSc degree and finishing with MSc. Additionally, my truly dedicated supervisors Dr. Daoud Al-Badriyeh and Dr. Hazem Elewa were always keen to provide me continuous support, and extensive personal and professional guidance. My overall experience as a postgraduate student in the College of Pharmacy was exceptional as the supportive research environment allowed me to have the opportunity to learn a valuable set of skills and knowledge. She added “I had a unique opportunity of being the president of the Interprofessional Education (IPE) Student Association that considerably enriched my personality”.
Sawsan’s was awarded the 5th Graduate Sponsorship Research Award, QNRF, Qatar Foundation. In addition, it has been evaluated competitively at different occasions, where she received the following in recognition of the quality of her MSc research including the second place at the TAD Bootcamp Award from the Office of Graduate Studies at the Qatar University Annual Research and best presentation award at the College of Pharmacy 9th Annual Student Research Forum.
Sawsan had participated in several international and national conferences including the International Conference for Healthcare and Medical Students in Ireland, the 9th International Pharmaceutical Care Conference in Oman, CUDOS Congress at Sidra Medicine, the College of Pharmacy 9th Annual Student Research Forum, and the 4th Qatar University Health Research Symposium. As well as, the abstract of this study was accepted in the 25th Annual International Meeting of the International Society of Pharmacoeconomics and Outcomes Research in the USA and the British Cardiovascular Society Annual Conference in the United Kingdom.