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Researcher: Dr. Hazem Elewa

Recent work focused on reviewing the role of genetic and non-genetic factors on warfarin dosing in the MENA region and in Qatari patients. Bader LA, Elewa H. [The Impact of Genetic and Non-Genetic Factors on Warfarin Dose Prediction in MENA Region: A Systematic Review. PloS one 11.12 (2016): e0168732.]

Researcher: Dr. Abdelali Agouni

Recent work led by Dr. Abdelali Agouni demonstrated for the first time the beneficial effects of pharmacological induction of Heme Oxygenase (HO)-1 in preventing high glucose-mediated activation of endoplasmic reticulum stress response in cultured endothelial cells leading to an improvement in endothelial dysfunction, the initial step in the development of atherosclerosis, characterized by a protection against endothelial cell death and improved angiogenic capacity. This work further highlighted the therapeutic potential of HO-1 induction in the treatment of cardiovascular complications of diabetes.

[Maamoun H, Zachariah 1, McVey JH, Green FR, Agouni A. Heme oxygenase (HO)-1 induction prevents Endoplasmic Reticulum stress-mediated endothelial cell death and impaired angiogenic capacity. Biochemical Pharmacology, 2017;127:46-59. doi: 10.1016/j.bcp.2016.12.009]

Brochur faculty research