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(QU-CPH) MSc graduate completed her Masters of Pharmacy (MSc) thesis titled ‘Cost-effectiveness Analysis of Ibuprofen versus Paracetamol for the Treatment of (PDA) in Preterm Neonates’ | Qatar University

(QU-CPH) MSc graduate completed her Masters of Pharmacy (MSc) thesis titled ‘Cost-effectiveness Analysis of Ibuprofen versus Paracetamol for the Treatment of (PDA) in Preterm Neonates’


MSc graduate of Qatar University’s College of Pharmacy (QU-CPH), Ms. Samaher Alshaibi recently completed and defended her Masters of Pharmacy (MSc) thesis titled ‘Cost-effectiveness Analysis of Ibuprofen versus Indomethacin or Paracetamol for the Treatment of Patent Ductus Arteriosus (PDA) in Preterm Neonates.

Under the supervision of Dr. Daoud Al-Badriyeh, a QU-CPH Associate Professor of Clinical Pharmacy and Practice, is an expert in Health Economics and Outcomes Research and is the principal supervisor of the research. A co-supervisor of the research is the QU-CPH Professor and Head of Clinical Pharmacy and Practice, Dr. Ahmed Awaisu.
The research study is the first health economics analysis, nationally and internationally, to evaluate the cost-effectiveness among all main pharmacotherapeutic options available for the closure of PDA in premature neonates in Qatar. It was conducted from the perspective of Women Wellness and Research Center, a member of the main healthcare provider in Qatar, Hamad Medical Corporation (HMC).

The optimal management of PDA, which is an opening between the two major blood vessels leading from the heart that fails to close after birth, is highly controversial and remains unclear as there are no universal guidelines or consensus regarding the most appropriate pharmacological treatment and route of administration. Currently, the selection of pharmacological treatment for PDA is dependent on individual institutions. In HMC in Qatar, the preferred first-line treatment is intravenous (IV) infusion ibuprofen, which is not based on any local comparative evidence, even though the IV indomethacin is also available in the HMC drug formulary for PDA closure. In Qatar, there is an increasing trend of using oral ibuprofen as well as oral paracetamol.

Currently, the simulation-based approach of evaluation is the future of healthcare and is appropriate. The current study was based on a hypothetical cohort of 5,000 neonates in Qatar. Economic and clinical data were obtained from robust meta-analyses as well as from local databases, and practice guidelines.

Ms. Samaher said, “While it is not easy to complete the MSc research within the minimum required duration, with the quality of mentorship I received, I always believed that I can do it. The topic of the research was of a particular interest to me, which I wanted to investigate and understand. But apart from the topic, I gained much research, communication and collaboration skills. I published in international journals, and presented at international events. I am very satisfied with how my MSc experiences and the outputs generated”.

She also added, “This analysis is the first economic evaluation in Qatar and the region evaluating ibuprofen versus indomethacin or ibuprofen versus paracetamol for PDA treatment in premature infants which can be a useful guide to decision makers on choosing evidence-based therapy. Further, as treatments in the neonatal intensive care unit (NICU) are highly costly, incorporating the cost factor when comparing different treatment options can help save hospital resources in the long run.”

Dr. Al-Badriyeh said, “This research is interesting. Ibuprofen and paracetamol are examples of cheap medications, not costing more than a few 100s of Qatari Riyals. One would assume that there is no point of performing any comparative economic evaluations among such medications. However, given the different consequences associated with drugs, the cost of a baby on these medications can vary between 300,000 and over 500,000 Qatari Riyal”. About Ms. Samaher, he added, “Samaher was most successful and she has put her heart, mind and soul into even the smallest detail in this project. Samaher loved the areas of her research, which is very important. She finished in the minimum required duration for the MSc completion and she generated several good publications. Her resolution to succeed is impressive and will surely take her places”.

Dr. Fatima Mraiche, Head of Research and Graduate Studies at QU-CPH said, “It is always a pleasure to see our students and faculty at QU-CPH address practice related questions using rigorous research methodology. This is a clear indication of the essential bridge between academy and practice, one which leads to progressive changes in the health and well-being of society.”

Related Files
  • (QU-CPH) MSc graduate completed her Masters of Pharmacy (MSc) thesis titled ‘Cost-effectiveness Analysis of Ibuprofen versus Paracetamol for the Treatment of (PDA) in Preterm Neonates’
  • (QU-CPH) MSc graduate with other officials